MSI's First AMD AM5 Motherboard And PSU With ATX12VO Break Cover
ATX12VO is an Intel standard, so you might not expect it to appear on AMD motherboards. Well, you'd be mistaken—ATX itself is an Intel standard, after all. The first company to show off a Socket AM5 motherboard designed for ATX12VO is MSI, who has at least a pair of boards on the way: the MSI PRO B650 12VO WiFi for Socket AM5, and the MSI PRO H610M 12VO for LGA 1700.
Both of the upcoming motherboards appear to be entry-level offerings, but it probably doesn't matter because they're not likely to appear on store shelves either way. MSI told the site that the upcoming hardware is primarily aimed at system integrators, and that it will also be offering its own-branded power supply to go along with the new motherboards. After all, you can't run ATX12VO off of a standard ATX PSU.
Indeed, that's why ATX12VO hasn't really penetrated the market despite being unveiled in 2019. There are really no downsides for consumers—you end up with cheaper and more efficient power supplies, cooler-running and quieter systems, and drastically less cabling to manage. It's possible that ATX12VO motherboards could be slightly more expensive than standard ATX boards, but fairly unlikely as it's much easier to step down from 12V to 5V or 3.3V on the motherboard if necessary, and in any case the cost should equalize. Hopefully we see more ATX12VO adoption in the DIY market in 2024.