In a job posting on AMD.com, it seems that the company is already looking for engineers to take on the challenge of the always shrinking die. AMD has started shipping 65 nm CPUs a few months ago, and one would imagine that 22 nm is probably a few years out at the least.
"DESCRIPTION OF POSITION: This position is for technical assignment within the AMD/IBM research alliance in New York. Primary responsibilities of this position will include generation of detailed lithography requirements for the 32 nm and 22 nm nodes, including overlay, CD, and focus budgets. Projects will consist of research in advanced optical lithography, EUV lithography, and alternative technologies directed toward development of lithographic solutions that meet these requirements."