I have a dual Dell monitor and Nvidia Quadro FX 4400 video card. When I tried to delete the Dell monitor's profile 2005FPW, I kept getting this error:

An error occurred while disassociating 2005FPW.icm

This happened to three computers that uses those two Dell monitors. None of the three computers can delete the 2005FPW profile.

Here's how I delete the profile.

Right click on desktop/choose Properties/Settings tab/click Advanced button/Color Management tab/select the 2005FPW color profile/choose Remove/then OK. When clicking the OK button, that's when I got the error above.

Dell suggested that I connect the two monitors directly to the computer instead of using DVI KVM switch. However, I don't think will make any difference. 

The reason I want to remove this profile is because I have an overlay problem. Whenever I play my video footage in Avid NLE, the image brightness looks okay, but as soon as I pause or stop playing, the video image looks much darker. And so I want Nvidia's settings to take over instead of using color management profile. 

Any other suggestion is welcome.

 What if you change the monitor device drivers to Generic in Device Manager, then try deleing the profile.  Once you remove the drivers, the profile may not know how to link to them again and let it be deleted.  Might require a reboot.

I tried that. I set Adobe1996 as my default profile and tried to delete the 2005FPW and I still have the same error.

 I think you misunderstood (or maybe I did).  I am not talking about profiles, go to Control Panel>System>Device Manager and look for your monitors in there.  Choose to update the driver and select a Generic one instead.  This may release your profiles so you can delete them.

 If you already did that, sorry for the duplication here :)